Frédérique Bidard-Michelot, a doctor in biochemistry, molecular and cellular biology from the University of Montpellier II, has dedicated her career to the study of ascomycete microorganisms (yeasts and fungi) using genetic, molecular biology, and systems biology approaches. She began her career in the field of oenology at UMR 1083 Sciences for Oenology. Her initial research focused on the genetic engineering of yeasts used in winemaking, a specialty she further developed at Lallemand SA, a global player in biotechnologies related to fermentation.
Frédérique continued her international journey, first in China, where she held a position in the scientific service of the French Embassy in Beijing and taught yeast genetics at Peking University (Beijing Daxue). Then, at the University of Copenhagen in Denmark, she worked under the direction of Professor O. Nielsen on fundamental issues of cell biology, particularly the study of cell fusion mechanisms in Schizosaccharomyces pombe yeast.
Upon her return to France, she turned to the field of systems biology through the study of the pathogenic yeast Candida albicans and the filamentous fungi Podospora anserina and Trichoderma reesei. These works were conducted in various laboratories (UMR Microbiology and Molecular Genetics, INRAE Center of Versailles-Grignon & Institute of Genetics and Microbiology, UMR8621, CNRS University Paris 11 & Institute of Biology of the École Normale Supérieure). For the past ten years, Frédérique has been working in the Biotechnology department of IFPEN. Her expertise focuses on the genetic engineering of Trichoderma reesei to enhance the production of cellulases, essential enzymes in industrial processes, utilizing her mastery of genomic, transcriptomic, and epigenomic data
- Development of integrative tools for the treatment of heterogeneous data from systems biology experimentation (in progress),
in collaboration with the IFPEN Signal Control Department and System and the Genomic Networks team of the Plant Sciences Institute (Paris-Saclay). - Profiling of secondary metabolites present in the secretomes of T. reesei strains (in progress),
in collaboration with the Fluid Characterization Department and the Polytechnic Institute of Paris (Palaiseau). - Studies of epigenetic regulations in enzyme production (2018-2022),
in collaboration with the Signal Control and System Department & the Epigenomics and Fungal Development team of the Integrative Cell Biology Institute (Université Paris Saclay, CNRS, CEA).
29 articles published in peer-reviewed journals
8 brevets
h-index 20
Chan Ho Tong L, Jourdier E, Naquin D, Ben Chaabane F, Aouam T, Chartier G, Castro González I, Margeot A, Bidard F. Transgressive phenotypes from outbreeding between the Trichoderma reesei hyper producer RutC30 and a natural isolate. Microbiol Spectr. 2024 12:e0044124.
doi: 10.1128/spectrum.00441-24.
Jagtap S, Pirayre A, Bidard F, Duval L, Malliaros FD. BRANEnet: embedding multilayer networks for omics data integration. BMC Bioinformatics. 2022 Oct 17;23(1):429.
doi: 10.1186/s12859-022-04955-w.
Pirayre A, Duval L, Blugeon C, Firmo C, Perrin S, Jourdier E, Margeot A, Bidard F. Glucose-lactose mixture feeds in industry-like conditions: a gene regulatory network analysis on the hyperproducing Trichoderma reesei strain Rut-C30. BMC Genomics. 2020 Dec 10;21(1):885.
doi: 10.1186/s12864-020-07281-8.
Jourdier E, Baudry L, Poggi-Parodi D, Vicq Y, Koszul R, Margeot A, Marbouty M, Bidard F. Proximity ligation scaffolding and comparison of two Trichoderma reesei strains genomes. Biotechnol Biofuels. 2017 Jun 12;10:151. doi: 10.1186/s13068-017-0837-6.